Social dominance in monkeys: dopamine D2
receptors and cocaine self-administration
Morgan D, Grant KA, Gage HD, Mach RH, Kaplan JR, Prioleau O,
Nader SH, Buchheimer N, Ehrenkaufer RL, Nader MA.
Department of Physiology and Pharmacology,
Wake Forest University School of Medicine,
Medical Center Boulevard, Winston-Salem,
North Carolina 27157, USA.
Nat Neurosci 2002 Jan 22
ABSTRACTDisruption of the dopaminergic system has been implicated in the etiology of many pathological conditions, including drug addiction. Here we used positron emission tomography (PET) imaging to study brain dopaminergic function in individually housed and in socially housed cynomolgus macaques (n = 20). Whereas the monkeys did not differ during individual housing, social housing increased the amount or availability of dopamine D2 receptors in dominant monkeys and produced no change in subordinate monkeys. These neurobiological changes had an important behavioral influence as demonstrated by the finding that cocaine functioned as a reinforcer in subordinate but not dominant monkeys. These data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction.History
Monkeys on coke
01 02 03 04 05 06 07 08 09 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?
The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family