Active cocaine immunization attenuates
the discriminative properties of cocaine

Johnson MW, Ettinger RH
Department of Psychology,
Eastern Oregon University,
La Grande 97850, USA.
Exp Clin Psychopharmacol 2000 May; 8(2):163-7


Anticocaine antibody, resulting from immunization with the cocaine-keyhole-limpet-hemocyanin (KLH) conjugate, weakened the ability of cocaine to act as a discriminative stimulus in rats. Subjects were given extensive training to discriminate 5.0 mg/kg of cocaine from saline prior to immunization. Several weeks following immunization with cocaine-KLH, subjects failed to reliably discriminate cocaine from saline. Nonimmunized control rats retained the ability to discriminate cocaine from saline throughout the experiment. These results further demonstrate that active immunization is effective in blunting cocaine effects. Immunized subjects were able to discriminate 20 mg/kg of cocaine, however, suggesting that anticocaine antibody may be overwhelmed by large cocaine doses.

Designer drugs
Vaccine dosage
Dopaminergic flies?
Dopaminergic agents
The coke-craving brain
Vaccines against drugs
Cocaine vaccine IPC-1010
Monoamines, cocaine and rats
Cocaine and artificial enzymes
Freebasing flies go hyperkinetic
Kappa receptors, dopamine D3 and cocaine
Therapeitic vaccines for substance dependence

01 02 03 04 05 06 07 08 09 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24

Future Opioids
BLTC Research
Wirehead Hedonism
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?

swan image
The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family